# name
HIV Incidence and Spatial Clustering in a Rural Area of Southern Mozambique

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BACKGROUND: Monitoring the HIV epidemic in a defined population
                is critical for planning treatment and preventive strategies.
                This is especially important in sub-Saharan Africa, which
                harbours the highest burden of the disease. OBJECTIVE: To
                estimate HIV incidence in adults aged 18-47 years old and to
                investigate spatial variations of HIV prevalence in Manhica, a
                semi-rural area of southern Mozambique. METHODS: Two
                cross-sectional community-based surveys were conducted in 2010
                and 2012 to determine HIV prevalence. Individual participants
                were randomly selected from the demographic surveillance system
                in place in the area and voluntary HIV counselling and testing
                was offered at the household level. HIV incidence was calculated
                using prevalence estimates from the two sero-surveys. Each
                participant's household was geocoded using a global information
                system. The Spatial Scan Statistics programme was used to
                identify areas with disproportionate excess in HIV prevalence.
                RESULTS: A total of 1511 adults were tested. The estimated HIV
                prevalence in the community was 39.9% in 2010 and 39.7% in 2012.
                The overall HIV incidence was 3.6 new infections per 100
                person-years at risk (PYAR) [95CI 1.56; 7.88], assuming stable
                epidemic conditions, and tended to be higher in women (4.9/100
                PYAR [95CI 1.74; 11.85]) than in men (3.2/PYAR [95CI 1.36;
                9.92]). One cluster with significant excess HIV prevalence was
                identified at the same geographic location in both surveys. This
                cluster had an HIV prevalence of 79.0% in 2010 and 52.3% in
                2012. CONCLUSIONS: The findings of these first
                individually-randomised community-HIV sero-surveys conducted in
                Mozambique reinforce the need to combine HIV incidence estimates
                and research on micro geographical infection patterns to guide
                and consolidate effective prevention strategies.

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Reproducció del document publicat a:
                http://dx.doi.org/10.1371/journal.pone.0132053

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
HIV Incidence and Spatial Clustering in a Rural Area of Southern Mozambique