# name
Synthesis of the ABC ring of calyciphylline A-type alkaloids by a stereocontrolled aldol cyclization: Formal synthesis of (±)-Himalensine A

# metadata.dc.description.abstract[].value
A synthetic approach to a functionalized ABC-tricyclic framework of calyciphilline A-type alkaloids, a building block toward this class of alkaloids, is reported. The key synthetic steps involve a radical cyclization to form the hydroindole system and piperidine ring closure through a stereocontrolled aldol cyclization. The resulting alcohol allows the methyl group to be installed in the bowl-shaped azatricyclic structure; this crucial reaction takes place with configuration retention. The synthesis of azatricyclic compound I constitutes a formal synthesis of himalensine A.

# metadata.dc.source[].value
Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

# metadata.dc.title[].value
Synthesis of the ABC ring of calyciphylline A-type alkaloids by a stereocontrolled aldol cyclization: Formal synthesis of (±)-Himalensine A