# name
Drug-Resistant Polymorphisms and Copy Numbers in Plasmodium
                falciparum, Mozambique, 2015

# metadata.dc.description.abstract[].value
One of the fundamental steps toward malaria control is the use
                of antimalarial drugs. The success of antimalarial treatment can
                be affected by the presence of drug-resistant populations of
                Plasmodium falciparum. To assess resistance, we used molecular
                methods to examine 351 P. falciparum isolates collected from 4
                sentinel sites in Mozambique for K13, pfmdr1, pfcrt, and pfdhps
                polymorphisms and for plasmepsin2 (pfpm2) and pfmdr1 copy
                numbers. We found multiple copies of pfpm2 in 1.1% of isolates.
                All isolates carried K13 wild-type alleles (3D7-like), except 4
                novel polymorphisms (Leu619Leu, Phe656Ile, Val666Val,
                Gly690Gly). Prevalence of isolates with pfcrt mutant (K76T)
                allele was low (2.3%). Prevalence of isolates with pfdhps mutant
                alleles (A437G and K540E) was >80%, indicating persistence of
                sulfadoxine/pyrimethamine resistance; however, markers of
                artemisinin were absent, and markers of piperaquine resistance
                were low. Piperaquine resistance isolates may spread in
                Mozambique as dihydroartemisinin/piperaquine drug pressure
                increases.

# metadata.dc.publisher[].value
Centers for Disease Control and Prevention

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Reproducció del document publicat a:
                http://dx.doi.org/10.3201/eid2401.170864

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Emerging Infectious Diseases, 2018, vol. 24, num. 1, p. 40-48

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Drug-Resistant Polymorphisms and Copy Numbers in Plasmodium
                falciparum, Mozambique, 2015