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Immune microenvironment and intrinsic subtyping in hormone receptor-positive/HER2-negative breast cancer

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Little is known regarding the interaction between immune microenvironment and tumorbiology in hormone receptor (HR)+/HER2− breast cancer (BC). We here assess pretreatmentgene-expression data from 66 HR+/HER2− early BCs from the LETLOB trial and show that non-luminal tumors (HER2-enriched, Basal-like) present higher tumor-infiltrating lymphocytelevels than luminal tumors. Moreover, significant differences in immune infiltrate composition,assessed by CIBERSORT, were observed: non-luminal tumors showed a more proinflammatoryantitumor immune infiltrate composition than luminal ones.

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Articles publicats en revistes (Medicina)

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Immune microenvironment and intrinsic subtyping in hormone receptor-positive/HER2-negative breast cancer