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Multiple immunofluorescence assay identifies upregulation of Active β-catenin in prostate cancer

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Objectives: To apply a systems pathology-based approach to the quantification of nuclear Active β-catenin and human leukocyte antigen class I, and assess the biomarker involvement in a cohort of prostate tumor patients. Results: The systems pathology approach applied allows a precise quantification of the marker expression in the different cell compartments as well as the determination of the areas that coexpress two markers. Our data shows that the accumulation of β-catenin in the nuclear compartment is significantly decreased in the adjacent normal areas when compared to tumor of the same patients (p < 0.001). In conclusion, the application of this novel multiple immunofluorescence assay demonstrates that the upregulation of Active β-catenin is a relatively common feature of prostate tumor development, and further supports the activation of the Wnt/β-catenin pathway in prostate cancer progression.

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BMC Research Notes, 2019, vol. 12, p. 68

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Articles publicats en revistes (Patologia i Terapèutica Experimental)

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Multiple immunofluorescence assay identifies upregulation of Active β-catenin in prostate cancer