# name
Estimating the efficacy of community-wide use of systemic
                insecticides in dogs to control zoonotic visceral leishmaniasis:
                A modelling study in a Brazilian scenario

# metadata.dc.description.abstract[].value
Systemic insecticides in dogs have been suggested as a public
                health intervention to prevent human cases of Zoonotic Visceral
                Leishmaniasis (ZVL). But, currently there are no systemic
                insecticides for dogs registered against zoo-anthropophilic pool
                blood feeding phlebotomine flies. We predict the impact of
                community-wide use of systemic insecticide in dog populations as
                a public health measure to control transmission of Leishmania
                infantum to humans using a mathematical model. We developed a
                Susceptible-Exposed-Infected (SEI) compartmental model to
                describe L. infantum transmission dynamics in dogs, with a
                vectorial capacity term to represent transmission between L.
                infantum-hosting dogs via phlebotomine flies. For Infected (I)
                dogs two levels of infectiousness were modelled, high
                infectiousness and low infectiousness. Human incidence was
                estimated through its relationship to infection in the dog
                population. We evaluated outcomes from a wide range of scenarios
                comprising different combinations of initial insecticide
                efficacy, duration of insecticide efficacy over time, and
                proportion of the dog population treated (60%, 70% & 80%).
                The same reduction in human infection incidence can be achieved
                via different combinations of insecticide efficacy, duration and
                dog coverage. For example, a systemic insecticide with an
                initial efficacy of 80% and 6 months above 65% efficacy would
                require treating at least 70% of the dogs to reduce the human
                infection incidence by 50%. Sensitivity analysis showed that the
                model outcome was most sensitive to baseline values of
                phlebotomine fly daily survival rate and insecticide coverage.
                Community-wide use of systemic insecticides applied to the "L.
                infantum canine reservoir" can significantly reduce human
                incidence of L. infantum infection. The results of this
                mathematical model can help defining the insecticide target
                product profile and how the insecticide should be applied to
                maximise effectiveness.

# metadata.dc.relation.ispartof[].value
PLOS Neglected Tropical Diseases, 2018, vol. 12, num. 9, p. e0006797

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Estimating the efficacy of community-wide use of systemic
                insecticides in dogs to control zoonotic visceral leishmaniasis:
                A modelling study in a Brazilian scenario