# name
Sustained malaria control over an eight-year period in Papua New
                Guinea: the challenge of low-density asymptomatic infections

# metadata.dc.description.abstract[].value
Background: The scale-up of effective malaria control in the
                last decade has resulted in a substantial decline in the
                incidence of clinical malaria in many countries. The effects on
                the proportions of asymptomatic and submicroscopic infections,
                and on transmission potential are yet poorly understood.
                Methods: In Papua New Guinea, vector control has been
                intensified since 2008, and improved diagnosis and treatment
                introduced in 2012. Cross-sectional surveys were conducted in
                Madang Province in 2006 (n=1280), 2010 (n=2117) and 2014
                (n=2516). Infections were quantified by highly sensitive qPCR
                and gametocytes by RT-qPCR. Results: P. falciparum prevalence by
                qPCR decreased from 42% in 2006 to 9% in 2014. P. vivax
                prevalence decreased from 42% in 2006 to 13% in 2010, but then
                increased to 20% in 2014. Parasite densities decreased 5-fold
                from 2006 to 2010; 72% of P. falciparum and 87% of P. vivax
                infections were submicroscopic in 2014. Gametocyte density and
                positivity correlated closely with parasitemia, and population
                gametocyte prevalence decreased 3-fold for P. falciparum and 29%
                for P. vivax from 2010 to 2014. Conclusions: Sustained control
                has resulted in reduced transmission potential but an increasing
                proportion of gametocyte carriers are asymptomatic and
                submicroscopic and represent a challenge to malaria control.

# metadata.dc.relation.isformatof[].value
Reproducció del document publicat a:
                http://dx.doi.org/10.1093/infdis/jix507

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Sustained malaria control over an eight-year period in Papua New
                Guinea: the challenge of low-density asymptomatic infections