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Thalamic Foxp2 regulates output connectivity and sensory‑motor impairments in a model of Huntington’s Disease

# metadata.dc.description.abstract[].value
Here, we demonstrate in a HD mouse model a clear and early thalamo-striatal aberrant connectivity associated with a reduction of thalamic Foxp2 levels. Recovering thalamic Foxp2 levels in the mouse rescued motor coordination and sensory skills concomitant with an amelioration of neuropathological features and with a repair of the structural and functional connectivity through a restoration of neurotransmitter release. In addition, reduction of thalamic Foxp2 levels in wild type mice induced HD-like phenotypes.

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Cellular and Molecular Life Sciences, 2023, vol. 80, num.12

# metadata.dc.rights[].value
cc by (c) Rodríguez Urgellés, Ened et al., 2023

# metadata.dc.source[].value
Articles publicats en revistes (Biomedicina)

# metadata.dc.title[].value
Thalamic Foxp2 regulates output connectivity and sensory‑motor impairments in a model of Huntington’s Disease