# name
The Oncomicrobiotics and the influence of the microbiota in the carcinogenesis

# metadata.dc.description[].value
Treballs Finals de Grau de Farmàcia, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, 2019. Tutor/a: David Miñana i Galbis

# metadata.dc.description.abstract[].value
The microbiome also known as “The forgotten organ” embraces the collective genome of all
bacteria, archaea, fungi, protists, and viruses found in the host body surfaces and cavities. It is
acknowledged that the microbiota has a role in many physiological functions such as the regulation
of inflammation, immune response or haematopoiesis among others. The involvement of dysbiosis
(alteration of the homeostatic microbiota) in the development of many pathologies like depression
or cancer is a current topic of interest. On the other hand, carcinogenesis results as an accumulation
of genetic and epigenetic alterations which are favoured by risk factors such as lifestyle, diet or
dysbiosis. The latter has recently been discovered to either contribute or prevent carcinogenesis by
modulating tumour or host cell microenvironment, respectively. Moreover, the microbiota has been
found to influence chemotherapy, radiotherapy and immunotherapy efficacy and toxicity.
Therefore, in this dissertation it is discussed the role of the microbiota as the cause, consequence
or both of carcinogenesis as well as the mechanisms and the bacterial species that are involved in
the efficacy or toxicity of certain anticancer drugs. It is relevant because it opens new strategies to
prevent cancer or to enhance therapeutic agents against cancer which could result in positive
clinical outcomes for cancer patients. One new strategy is the oncomicrobiotics, a select “cocktail
of bacteria and/or bacterial products” as an adjunctive therapy to cancer with the intention of
improving the immune response through optimizing the gut microbiota.

# metadata.dc.rights[].value
cc-by-nc-nd (c) Ignasi Parés Bofill, 2019

# metadata.dc.source[].value
Treballs Finals de Grau (TFG) - Farmàcia

# metadata.dc.title[].value
The Oncomicrobiotics and the influence of the microbiota in the carcinogenesis