# name
Prevalence and Evolution of Renal Impairment in People Living
                With HIV in Rural Tanzania

# metadata.dc.description.abstract[].value
Background: We assessed the prevalence, incidence, and
                predictors of renal impairment among people living with HIV
                (PLWHIV) in rural Tanzania. Methods: In a cohort of PLWHIV aged
                >/=15 years enrolled from January 2013 to June 2016, we
                assessed the association between renal impairment (estimated
                glomerural filtration rate < 90 mL/min/1.73 m(2)) at
                enrollment and during follow-up with demographic and clinical
                characteristcis using logistic regression and Cox proportional
                hazards models. Results: Of 1093 PLWHIV, 172 (15.7%) had renal
                impairment at enrollment. Of 921 patients with normal renal
                function at baseline, 117 (12.7%) developed renal impairment
                during a median follow-up (interquartile range) of 6.2
                (0.4-14.7) months. The incidence of renal impairment was 110
                cases per 1000 person-years (95% confidence interval [CI],
                92-132). At enrollment, logistic regression identified older age
                (adjusted odds ratio [aOR], 1.79; 95% CI, 1.52-2.11),
                hypertension (aOR, 1.84; 95% CI, 1.08-3.15), CD4 count <200
                cells/mm(3) (aOR, 1.80; 95% CI, 1.23-2.65), and World Health
                Organization (WHO) stage III/IV (aOR, 3.00; 95% CI, 1.96-4.58)
                as risk factors for renal impairment. Cox regression model
                confirmed older age (adjusted hazard ratio [aHR], 1.85; 95% CI,
                1.56-2.20) and CD4 count <200 cells/mm(3) (aHR, 2.05; 95% CI,
                1.36-3.09) to be associated with the development of renal
                impairment. Conclusions: Our study found a low prevalence of
                renal impairment among PLWHIV despite high usage of tenofovir
                and its association with age, hypertension, low CD4 count, and
                advanced WHO stage. These important and reassuring safety data
                stress the significance of noncommunicable disease surveillance
                in aging HIV populations in sub-Saharan Africa.

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Reproducció del document publicat a:
                http://dx.doi.org/10.1093/ofid/ofy072

# metadata.dc.relation.ispartof[].value
Open Forum Infectious Diseases, 2018, vol. 5, num. 4

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Prevalence and Evolution of Renal Impairment in People Living
                With HIV in Rural Tanzania