# name
Association between kidney function, nutritional status and anthropometric measures in older people. The Screening for CKD among Older People across Europe (SCOPE) study

# metadata.dc.description.abstract[].value
Background: Different mechanisms connect the nutritional status with the occurrence and the course of chronic
kidney disease (CKD). The end-stage renal disease is complicated by catabolic inflammatory reactions and cachexia
which leads to malnutrition (undernutrition). On the other hand, obesity is an important risk factor for the
development and acceleration of CKD.
Methods: In the SCOPE study, community-dwelling persons aged 75 years and over, from 6 European countries
and Israel were examined at the baseline phase. We assessed the relationship between anthropometric measures
(Body Mass Index (BMI), circumferences of arm (AC), waist (WC), hip (HC), and calf (CC), waist-to-hip ratio - WHR,
waist-to-height ratio - WHtR, risk of malnutrition (Mini Nutritional Assessment - MNA), serum albumin) and
estimated glomerular filtration rate (eGFR) calculated by Berlin Initiative Study (BIS) equation. Results: We studied 2151 subjects (932 men and 1219 women) with a mean age of 79.5 ± 5.9 years. A total of 1333
(62%) participants had CKD (GRF < 60 ml/min/1.73 m2
). Negative correlations between eGFR and weight, AC, WC,
HC, CC, BMI, WHtR were observed. Positive correlation occurred between eGFR and MNA score (Spearman’s rho =
0.11) and albumin concentration (rho = 0.09). Higher weight, AC, WC, HC, CC, BMI and WHtR increased the odds
ratio of CKD; higher MNA (OR = 0.98, 95% CI 0.94–1.0) and higher serum albumin (OR = 0.73, 95% CI 0.53–1.0) were
weakly associated with reduced odds. The risk of malnutrition was the highest with eGFR < 30 as compared to
eGFR > 60 (OR = 2.95, 95%CI = 1.77–4.94 for MNA < 24; OR = 5.54, 95%CI = 1.66–18.5 for hypoalbuminemia < 3.5 g/
dL).
Conclusion: The population of community dwelling people aged 75+ with CKD shows general features of
overweight and obesity with a small prevalence of malnutrition. For anthropometric measures, the strongest
association with eGFR and the highest odds of CKD were identified using WC, HC, CC and WHtR. Albumin level and
MNA, but not MNA Short Form, indicated an increased odds of malnutrition with a decrease in eGFR.

# metadata.dc.source[].value
Articles publicats en revistes (Ciències Clíniques)

# metadata.dc.title[].value
Association between kidney function, nutritional status and anthropometric measures in older people. The Screening for CKD among Older People across Europe (SCOPE) study