# name
Novel strategies against cancer: dexibuprofen loaded nanostructured lipid carriers

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The aim of this work was to design innovative nanostructured lipid carriers (NLCs) for  the delivery of dexibuprofen (DXI) as an antiproliferative therapy against tumoral processes, and  overcome its side effects. DXI-NLC samples were prepared with beeswax, Miglyol 812 and Tween  80 using high-pressure homogenization. A two-level factorial design 24 was applied to optimize  the formulation, and physicochemical properties such as particle size, zeta potential, polydispersity index and entrapment efficiency were measured. Optimized parameters of DXI-NLCs exhibited a mean particle size of 152.3 nm, a polydispersity index below 0.2, and high DXI entrapment efficiency (higher than 99%). Moreover, DXI-NLCs provided a prolonged drug release, slower than the free DXI.  DXI-NLCs were stable for 2 months and their morphology revealed that they possess a spherical  shape. In vitro cytotoxicity and anticancer potential studies were performed towards prostate (PC-3) and breast (MDA-MB-468) cancer cell lines. The highest activity of DXI-NLCs was observed towards breast cancer cells, which were effectively inhibited at 3.4 μM. Therefore, DXI-NLCs constitute a promising antiproliferative therapy that has proven to be especially effective against breast cancer.

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International Journal of Molecular Sciences, 2022, vol. 23

# metadata.dc.rights[].value
cc-by (c)  Thiruchenthooran, V. et al., 2022

# metadata.dc.source[].value
Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)

# metadata.dc.title[].value
Novel strategies against cancer: dexibuprofen loaded nanostructured lipid carriers