# name
RTS,S/AS01E Malaria Vaccine Induces Memory and Polyfunctional T
                Cell Responses in a Pediatric African Phase III Trial

# metadata.dc.description.abstract[].value
Comprehensive assessment of cellular responses to the
                RTS,S/AS01E vaccine is needed to understand potential correlates
                and ultimately mechanisms of protection against malaria disease.
                Cellular responses recognizing the RTS,S/AS01E-containing
                circumsporozoite protein (CSP) and Hepatitis B surface antigen
                (HBsAg) were assessed before and 1 month after primary
                vaccination by intracellular cytokine staining and 16-color flow
                cytometry in 105 RTS,S/AS01-vaccinated and 74 rabies-vaccinated
                participants (controls) in a pediatric phase III trial in
                Africa. RTS,S/AS01E-vaccinated children had significantly higher
                frequencies of CSP- and HBsAg-specific CD4+ T cells producing
                IL-2, TNF-alpha, and CD40L and HBsAg-specific CD4+ T producing
                IFN-gamma and IL-17 than baseline and the control group.
                Vaccine-induced responses were identified in both central and
                effector memory (EM) compartments. EM CD4+ T cells expressing
                IL-4 and IL-21 were detected recognizing both vaccine antigens.
                Consistently higher response rates to both antigens in
                RTS,S/AS01E-vaccinated than comparator-vaccinated children were
                observed. RTS,S/AS01E induced polyfunctional CSP- and
                HBsAg-specific CD4+ T cells, with a greater degree of
                polyfunctionality in HBsAg responses. In conclusion, RTS,S/AS01E
                vaccine induces T cells of higher functional heterogeneity and
                polyfunctionality than previously characterized. Responses
                detected in memory CD4+ T cell compartments may provide
                correlates of RTS,S/AS01-induced immunity and duration of
                protection in future correlates of immunity studies.

# metadata.dc.relation.isformatof[].value
Reproducció del document publicat a:
                http://dx.doi.org/10.3389/fimmu.2017.01008

# metadata.dc.relation.ispartof[].value
Frontiers in Immunology, 2017, vol. 8, p. 1008

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
RTS,S/AS01E Malaria Vaccine Induces Memory and Polyfunctional T
                Cell Responses in a Pediatric African Phase III Trial