# name
Vaginal versus Obstetric Infection Escherichia coli Isolates
                among Pregnant Women: Antimicrobial Resistance and Genetic
                Virulence Profile

# metadata.dc.description.abstract[].value
Vaginal Escherichia coli colonization is related to obstetric
                infections and the consequent development of infections in
                newborns. Ampicillin resistance among E. coli strains is
                increasing, which is the main choice for treating empirically
                many obstetric and neonatal infections. Vaginal E. coli strains
                are very similar to extraintestinal pathogenic E. coli with
                regards to the virulence factors and the belonging to phylogroup
                B2. We studied the antimicrobial resistance and the genetic
                virulence profile of 82 E. coli isolates from 638 vaginal
                samples and 63 isolated from endometrial aspirate, placental and
                amniotic fluid samples from pregnant women with obstetric
                infections. The prevalence of E. coli in the vaginal samples was
                13%, which was significant among women with associated risk
                factors during pregnancy, especially premature preterm rupture
                of membranes (p<0.0001). Sixty-five percent of the strains
                were ampicillin-resistant. The E. coli isolates causing
                obstetric infections showed higher resistance levels than
                vaginal isolates, particularly for gentamicin (p = 0.001). The
                most prevalent virulence factor genes were those related to the
                iron uptake systems revealing clear targets for interventions.
                More than 50% of the isolates belonged to the virulent B2 group
                possessing the highest number of virulence factor genes. The
                ampicillin-resistant isolates had high number of virulence
                factors primarily related to pathogenicity islands, and the
                remarkable gentamicin resistance in E. coli isolates from women
                presenting obstetric infections, the choice of the most
                appropriate empiric treatment and clinical management of
                pregnant women and neonates should be carefully made. Taking
                into account host-susceptibility, the heterogeneity of E. coli
                due to evolution over time and the geographical area,
                characterization of E. coli isolates colonizing the vagina and
                causing obstetric infections in different regions may help to
                develop interventions and avoid the aetiological link between
                maternal carriage and obstetric and subsequent puerperal
                infections.

# metadata.dc.relation.isformatof[].value
Reproducció del document publicat a:
                http://dx.doi.org/10.1371/journal.pone.0146531

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Vaginal versus Obstetric Infection Escherichia coli Isolates
                among Pregnant Women: Antimicrobial Resistance and Genetic
                Virulence Profile