# name
In-Vivo Efficacy of Chloroquine to Clear Asymptomatic Infections
                in Mozambican Adults: A Randomized, Placebo-controlled Trial
                with Implications for Elimination Strategies

# metadata.dc.description.abstract[].value
Recent reports regarding the re-emergence of parasite
                sensitivity to chloroquine call for a new consideration of this
                drug as an interesting complementary tool in malaria elimination
                efforts, given its good safety profile and long half-life. A
                randomized (2:1), single-blind, placebo-controlled trial was
                conducted in Manhica, Mozambique, to assess the in-vivo efficacy
                of chloroquine to clear plasmodium falciparum (Pf) asymptomatic
                infections. Primary study endpoint was the rate of adequate and
                parasitological response (ACPR) to therapy on day 28
                (PCR-corrected). Day 0 isolates were analyzed to assess the
                presence of the PfCRT-76T CQ resistance marker. A total of 52
                and 27 male adults were included in the CQ and Placebo group
                respectively. PCR-corrected ACPR was significantly higher in the
                CQ arm 89.4% (95%CI 80-98%) compared to the placebo (p <
                0.001). CQ cleared 49/50 infections within the first 72 h while
                placebo cleared 12/26 (LRT p < 0.001). The PfCRT-76T mutation
                was present only in one out of 108 (0.9%) samples at baseline,
                well below the 84% prevalence found in 1999 in the same area.
                This study presents preliminary evidence of a return of
                chloroquine sensitivity in Mozambican Pf isolates, and calls for
                its further evaluation in community-based malaria elimination
                efforts, in combination with other effective anti-malarials.
                TRIAL REGISTRATION: www.clinicalTrials.gov NCT02698748.

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
In-Vivo Efficacy of Chloroquine to Clear Asymptomatic Infections
                in Mozambican Adults: A Randomized, Placebo-controlled Trial
                with Implications for Elimination Strategies