# name
Explicit criteria for Potentially Inappropriate Medications in Older Adults: A comprehensive systematic review.

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Context: Potentially inappropriate medications (PIMs) refer to the use of a medication whose risks outweigh the potential benefits in older adults, especially when other effective alternatives are available.

Aims: To identify and analyze explicit criteria developed for detecting PIMs in older adults, highlighting methodological approaches and pharmacological classifications.

Methods: A comprehensive literature search was conducted across seven databases from January 1990 to December 2024, following the PRISMA 2020 guidelines. Criteria developed using expert consensus or evidence-based processes were included.

Results: Out of 3,119 articles, 68 met the inclusion criteria. The Beers and STOPP/START tools were most frequently cited. The Delphi method was the predominant approach for validating the selected tools (73.53%). Commonly flagged medications included tricyclic antidepressants, NSAIDs, and benzodiazepines.

Conclusions: Numerous validated tools exist, although variations in validation methods and drug classification were observed. A global update and harmonization of explicit criteria are necessary for improved geriatric pharmacotherapy.

Keywords: Beers criteria; Delphi method; deprescribing tools; older adults; potentially inappropriate medications; STOPP START criteria.

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Journal of Pharmacy & Pharmacognosy Research, 2025, vol. 13, num.6, p. 1797-1818

# metadata.dc.rights[].value
cc-by-nc (c)  Alemán-Fernández E et al., 2025

# metadata.dc.source[].value
Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)

# metadata.dc.title[].value
Explicit criteria for Potentially Inappropriate Medications in Older Adults: A comprehensive systematic review.