# name
Blood Interferon Signatures Putatively Link Lack of Protection
                Conferred by the RTS,S Recombinant Malaria Vaccine to an
                Antigen-specific IgE Response

# metadata.dc.description.abstract[].value
Malaria remains a major cause of mortality and morbidity
                worldwide. Progress has been made in recent years with the
                development of vaccines that could pave the way towards
                protection of hundreds of millions of exposed individuals. Here
                we used a modular repertoire approach to re-analyze a publically
                available microarray blood transcriptome dataset monitoring the
                response to malaria vaccination. We report the seminal
                identification of interferon signatures in the blood of subjects
                on days 1, 3 and 14 following administration of the third dose
                of the RTS,S recombinant malaria vaccine. These signatures at
                day 1 correlate with protection, and at days 3 and 14 to
                susceptibility to subsequent challenge of study subjects with
                live parasites. In addition we putatively link the decreased
                abundance of interferon-inducible transcripts observed at days 3
                and 14 post-vaccination with the elicitation of an
                antigen-specific IgE response in a subset of vaccine recipients
                that failed to be protected by the RTS,S vaccine. Furthermore,
                profiling of antigen-specific levels of IgE in a Mozambican
                cohort of malaria-exposed children vaccinated with RTS,S
                identified an association between elevated baseline IgE levels
                and subsequent development of naturally acquired malaria
                infection during follow up. Taken together these findings
                warrant further investigation of the role of antigen-specific
                IgE in conferring susceptibility to malaria infection.

# metadata.dc.relation.isformatof[].value
Reproducció del document publicat a:
                http://dx.doi.org/10.12688/f1000research.7093.2

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Blood Interferon Signatures Putatively Link Lack of Protection
                Conferred by the RTS,S Recombinant Malaria Vaccine to an
                Antigen-specific IgE Response