# name
Development of a microphysiological system with integrated electrodes for  cardiac cell culture, stimulation and  sensing

# metadata.dc.description[].value
Treballs Finals de Grau d'Enginyeria Biomèdica. Facultat de Medicina i Ciències de la Salut. Universitat de Barcelona. Curs: 2022-2023. Tutor/Director: Rodríguez Trujillo, Romen

# metadata.dc.description.abstract[].value
This project focuses on the development and experimentation of a microfluidic device with 
integrated electrodes, specifically designed to support the growth and maturation of a 3D cardiac 
cell matrix. The goal is to create a functional system that not only enables the cells to thrive and 
pump, but also facilitates the propagation of electrical stimuli, mimicking the behavior of natural 
cardiovascular tissue.
The motivation behind this research stems from the limited regenerative capacity of adult heart 
tissue, particularly when it comes to cardiomyocytes. Traditional healing methods are often 
inadequate, necessitating heart transplants as the only definitive treatment option. To address this 
challenge, scientists are exploring the potential of biomaterial scaffolds to regenerate 
cardiovascular tissue by replacing damaged or necrotic tissue.
The microfluidic device developed in this project holds great promise for researchers in the 
pharmaceutical field, offering a valuable tool for drug testing and disease modeling. Despite facing 
challenges in incorporating gold electrodes into the device, the team has successfully characterized 
it using an EIS machine. The design of the microelectrodes and microchannels, along with the 
overall functionality of the microchip, have been accomplished. While the current focus has been 
on a 2D layer of cells, the future objectives involve achieving a fully functional 3D matrix to fulfill 
the original research goals.
Overall, this project aims to represent a significant step towards the advancement of regenerative 
medicine and the potential for innovative solutions in treating cardiovascular diseases.

# metadata.dc.rights[].value
cc-by-nc-nd (c) Berta Lloveras Borràs, 2023

# metadata.dc.source[].value
Treballs Finals de Grau (TFG) - Enginyeria Biomèdica

# metadata.dc.title[].value
Development of a microphysiological system with integrated electrodes for  cardiac cell culture, stimulation and  sensing