# metadata.dc.description.abstract[].value
Organisms with identical genome sequences can show substantial
                differences in their phenotypes owing to epigenetic changes that
                result in different use of their genes. Epigenetic regulation of
                gene expression plays a key role in the control of several
                fundamental processes in the biology of malaria parasites,
                including antigenic variation and sexual differentiation. Some
                of the histone modifications and chromatin-modifying enzymes
                that control the epigenetic states of malaria genes have been
                characterized, and their functions are beginning to be
                unraveled. The fundamental principles of epigenetic regulation
                of gene expression appear to be conserved between malaria
                parasites and model eukaryotes, but important peculiarities
                exist. Here, we review the current knowledge of malaria
                epigenetics and discuss how it can be exploited for the
                development of new molecular markers and new types of drugs that
                may contribute to malaria eradication efforts.

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Verisó postprint del document publicat a:
                http://dx.doi.org/10.1101/cshperspect.a025528

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Cold Spring Harbor Perspectives in Medicine, 2017

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(c) Cold Spring Harbor Laboratory Press, 2017

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Articles publicats en revistes (ISGlobal)