# name
Lymphocytopenia as a Predictor of Mortality in Patients with ICU-Acquired Pneumonia

# metadata.dc.description.abstract[].value
Background: Intensive care unit-acquired pneumonia (ICU-AP) is a severe complication
in patients admitted to the ICU. Lymphocytopenia is a marker of poor prognosis in patients
with community-acquired pneumonia, but its impact on ICU-AP prognosis is unknown.
We aimed to evaluate whether lymphocytopenia is an independent risk factor for mortality in
non-immunocompromised patients with ICU-AP. Methods: Prospective observational cohort study
of patients from six ICUs of an 800-bed tertiary teaching hospital (2005 to 2016). Results: Of the
473 patients included, 277 (59%) had ventilator-associated pneumonia (VAP). Receiver operating
characteristic (ROC) analysis of the lymphocyte counts at diagnosis showed that 595 cells/mm3 was
the best cut-off for discriminating two groups of patients at risk: lymphocytopenic group (lymphocyte
count <595 cells/mm3
, 141 patients (30%)) and non-lymphocytopenic group (lymphocyte count
≥595 cells/mm3
, 332 patients (70%)). Patients with lymphocytopenia presented more comorbidities
and a higher sequential organ failure assessment (SOFA) score at the moment of pneumonia
diagnosis. Also, 28-day mortality and 90-day mortality were higher in patients with lymphocytopenia
(28-day: 38 (27%) versus 59 (18%), 90-day: 74 (53%) versus 111 (34%)). In the multivariable model,
<595 cells/mm3
resulted to be an independent predictor for 90-day mortality (Hazard Ratio 1.41;
95% Confidence Interval 1.02 to 1.94). Conclusion: Lymphocytopenia is an independent predictor of
90-day mortality in non-immunocompromised patients with ICU-AP.

# metadata.dc.relation.ispartof[].value
Journal of Clinical Medicine, 2019, vol. 8, num. 6, 843

# metadata.dc.source[].value
Articles publicats en revistes (Medicina)

# metadata.dc.title[].value
Lymphocytopenia as a Predictor of Mortality in Patients with ICU-Acquired Pneumonia