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Rhinovirus Species and Clinical Features in Children
                Hospitalized with Pneumonia from Mozambique

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OBJECTIVES: To describe the prevalence of human rhinovirus (RV)
                species in children hospitalized with pneumonia in Manhica,
                Mozambique; and the associations between RV species and
                demographic, clinical, and laboratory features. METHODS:
                Nasopharyngeal aspirates were collected from children 0-10 years
                of age (n=277) presenting to Manhica District Hospital with
                clinical pneumonia. Blood samples were collected for HIV and
                malaria testing, blood culture and full blood counts, and a
                chest X-ray was performed. A panel of common respiratory viruses
                was investigated using two independent multiplex RT-PCR assays
                with primers specific for each virus and viral type. RV species
                and genotypes were identified by semi-nested PCR assays,
                sequencing and phylogenetic tree analyses. RESULTS: At least one
                respiratory virus was identified in 206 (74.4%) children
                hospitalized with clinical pneumonia. RV was the most common
                virus identified in both HIV-infected (17/38, 44.7%) and
                HIV-uninfected (74/237, 31.2%; p=0.100) children. RV-A was the
                most common RV species identified (47/275, 17.0%), followed by
                RV-C (35/275, 12.6%) and RV-B (8/275, 2.9%). Clinical
                presentation of the different RV species was similar and
                overlapping, with no particular species being associated with
                specific clinical features. CONCLUSIONS: RV-A and RV-C were the
                most common respiratory viruses identified in children
                hospitalised with clinical pneumonia in Manhica. Clinical
                presentation of RV-A and RV-C was similar and overlapping. This
                article is protected by copyright. All rights reserved.

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Versió postprint del document publicat a:
                http://dx.doi.org/10.1111/tmi.12743

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Tropical Medicine & International Health, 2016

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Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Rhinovirus Species and Clinical Features in Children
                Hospitalized with Pneumonia from Mozambique