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Efficacy and safety of direct-acting antiviral agents when combined with secukinumab

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Background: The interference in the immune response induced by biological disease-modifying antirheumatic drugs (bDMARDs) increases the risk of reactivation of infections. Treatment of patients with chronic hepatitis C virus (HCV) infection and psoriasis is complex. The efficacy and safety of the new direct-acting antiviral agents (DAA) when combined with bDMARDs remain unknown. Case report: We present a case of a 44-year-old Caucasian man affected with psoriasis and HCV infection. Throughout the course of the psoriatic disease, this patient received several lines of treatment, including secukinumab, a new type of bDMARD. At the time of commencing secukinumab, new DAA agents (ledipasvir/sofosbuvir) were also initiated. At week 12 post-treatment, hepatitis C viral load was undetectable and the patient remained in remission of psoriasis. Conclusion: This case report suggests that secukinumab is a therapeutic option in patients with psoriasis, particularly in those cases with HCV infection where treatment with DAA agents is warranted.

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European Journal Of Hospital Pharmacy-Science And Practice, 2018, vol. 25, num. 1, p. 53-56

# metadata.dc.rights[].value
(c) European Association of Hospital Pharmacists, 2018

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Articles publicats en revistes (Medicina)

# metadata.dc.title[].value
Efficacy and safety of direct-acting antiviral agents when combined with secukinumab