# name
malERA: An updated research agenda for combination interventions
                and modelling in malaria elimination and eradication

# metadata.dc.contributor.author[].value
malERA Refresh Consultative Panel on Combination Interventions and Modelling

# metadata.dc.description.abstract[].value
This paper summarises key advances and priorities since the 2011
                presentation of the Malaria Eradication Research Agenda
                (malERA), with a focus on the combinations of intervention tools
                and strategies for elimination and their evaluation using
                modelling approaches. With an increasing number of countries
                embarking on malaria elimination programmes, national and local
                decisions to select combinations of tools and deployment
                strategies directed at malaria elimination must address rapidly
                changing transmission patterns across diverse geographic areas.
                However, not all of these approaches can be systematically
                evaluated in the field. Thus, there is potential for modelling
                to investigate appropriate 'packages' of combined interventions
                that include various forms of vector control, case management,
                surveillance, and population-based approaches for different
                settings, particularly at lower transmission levels. Modelling
                can help prioritise which intervention packages should be tested
                in field studies, suggest which intervention package should be
                used at a particular level or stratum of transmission intensity,
                estimate the risk of resurgence when scaling down specific
                interventions after local transmission is interrupted, and
                evaluate the risk and impact of parasite drug resistance and
                vector insecticide resistance. However, modelling intervention
                package deployment against a heterogeneous transmission
                background is a challenge. Further validation of malaria models
                should be pursued through an iterative process, whereby field
                data collected with the deployment of intervention packages is
                used to refine models and make them progressively more relevant
                for assessing and predicting elimination outcomes.

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Reproducció del document publicat a:
                http://dx.doi.org/10.1371/journal.pmed.1002453

# metadata.dc.rights[].value
cc by (c) malERA Refresh Consultative Panel on Combination Interventions and Modelling, 2017

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
malERA: An updated research agenda for combination interventions
                and modelling in malaria elimination and eradication