# name
A fast method to monitor tyrosine kinase inhibitors mechanisms

# metadata.dc.description.abstract[].value
Methionine residues within the kinase domain of Src serve as unique NMR probes capable of distinguishing between distinct conformational states of full-length Src, including alternative drug-inhibited forms. This approach offers a rapid method to differentiate between various inhibition mechanisms at any stage of drug development, eliminating the need to resolve the structure of Src-drug complexes. Using selectively 13C-methyl-enriched methionine, spectra can be acquired in under an hour, while natural abundance spectra with comparable information are achievable within a few hours.

# metadata.dc.rights[].value
cc-by (c) Fernández, Alejandro et al., 2024

# metadata.dc.source[].value
Articles publicats en revistes (Química Inorgànica i Orgànica)

# metadata.dc.title[].value
A fast method to monitor tyrosine kinase inhibitors mechanisms