# name
Incidence of Tuberculosis Among Young Children in Rural
                Mozambique

# metadata.dc.description.abstract[].value
BACKGROUND: Tuberculosis (TB) contributes significantly to child
                morbidity and mortality. This study aimed to estimate the
                minimum community-based incidence rate of TB among children
                <3 years of age in Southern Mozambique. METHODS: Between
                October 2011 and October 2012, in the Manhica District Health
                and Demographic Surveillance System, we enrolled prospectively
                all presumptive TB cases younger than 3 years of age through
                passive and active case finding. Participants included all
                children who were either symptomatic or were close contacts of a
                notified adult smear-positive pulmonary TB. Children were
                clinically evaluated at baseline and follow-up visits.
                Investigation for TB disease included chest radiography, HIV and
                tuberculin skin testing as well as gastric aspirate and induced
                sputum sampling, which were processed for smear, culture and
                mycobacterial molecular identification. RESULTS: During the
                study period, 13,764 children <3 years contributed to a total
                of 9575 person-year. Out of the 789 presumptive TB cases
                enrolled, 13 had TB culture confirmation and 32 were probable TB
                cases. The minimum community-based incidence rate of TB
                (confirmed plus probable cases) was 470 of 100,000 person-year
                (95% confidence interval: 343-629 of 100,000). HIV co-infection
                was present in 44% of the TB cases. CONCLUSION: These data
                highlight the huge burden of pediatric TB. This study provides
                one of the first prospective population-based incidence data of
                childhood tuberculosis and adds valuable information to the
                global effort of producing better estimates, a critical step to
                inform public health policy.

# metadata.dc.relation.isformatof[].value
Versió postprint del document publicat a:
                http://dx.doi.org/10.1097/INF.0000000000000710

# metadata.dc.relation.ispartof[].value
The Pediatric Infectious Disease Journal, 2015, vol. 34, num. 7,
                p. 686-692

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Incidence of Tuberculosis Among Young Children in Rural
                Mozambique