# name
Evolution of the Quorum network and the mobilome (plasmids and
                bacteriophages) in clinical strains of Acinetobacter baumannii
                during a decade

# metadata.dc.description.abstract[].value
In this study, we compared eighteen clinical strains of A.
                baumannii belonging to the ST-2 clone and isolated from patients
                in the same intensive care unit (ICU) in 2000 (9 strains
                referred to collectively as Ab_GEIH-2000) and 2010 (9 strains
                referred to collectively as Ab_GEIH-2010), during the GEIH-REIPI
                project (Umbrella BioProject PRJNA422585). We observed two main
                molecular differences between the Ab_GEIH-2010 and the
                Ab_GEIH-2000 collections, acquired over the course of the decade
                long sampling interval and involving the mobilome: i) a plasmid
                harbouring genes for blaOXA 24/40 ss-lactamase and abKA/abkB
                proteins of a toxin-antitoxin system; and ii) two temperate
                bacteriophages, Ab105-1varphi (63 proteins) and Ab105-2varphi
                (93 proteins), containing important viral defence proteins.
                Moreover, all Ab_GEIH-2010 strains contained a Quorum functional
                network of Quorum Sensing (QS) and Quorum Quenching (QQ)
                mechanisms, including a new QQ enzyme, AidA, which acts as a
                bacterial defence mechanism against the exogenous 3-oxo-C12-HSL.
                Interestingly, the infective capacity of the bacteriophages
                isolated in this study (Ab105-1varphi and Ab105-2varphi) was
                higher in the Ab_GEIH-2010 strains (carrying a functional Quorum
                network) than in the Ab_GEIH-2000 strains (carrying a deficient
                Quorum network), in which the bacteriophages showed little or no
                infectivity. This is the first study about the evolution of the
                Quorum network and the mobilome in clinical strains of
                Acinetobacter baumannii during a decade.

# metadata.dc.relation.ispartof[].value
Scientific Reports, 2018, vol. 8, num. 2523

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Evolution of the Quorum network and the mobilome (plasmids and
                bacteriophages) in clinical strains of Acinetobacter baumannii
                during a decade