# name
Global, regional, and national disease burden estimates of acute
                lower respiratory infections due to respiratory syncytial virus
                in young children in 2015: a systematic review and modelling
                study

# metadata.dc.contributor.author[].value
de Freitas Lazaro Emediato, Carla Cecília

# metadata.dc.description.abstract[].value
BACKGROUND: We have previously estimated that respiratory
                syncytial virus (RSV) was associated with 22% of all episodes of
                (severe) acute lower respiratory infection (ALRI) resulting in
                55 000 to 199 000 deaths in children younger than 5 years in
                2005. In the past 5 years, major research activity on RSV has
                yielded substantial new data from developing countries. With a
                considerably expanded dataset from a large international
                collaboration, we aimed to estimate the global incidence,
                hospital admission rate, and mortality from RSV-ALRI episodes in
                young children in 2015. METHODS: We estimated the incidence and
                hospital admission rate of RSV-associated ALRI (RSV-ALRI) in
                children younger than 5 years stratified by age and World Bank
                income regions from a systematic review of studies published
                between Jan 1, 1995, and Dec 31, 2016, and unpublished data from
                76 high quality population-based studies. We estimated the
                RSV-ALRI incidence for 132 developing countries using a risk
                factor-based model and 2015 population estimates. We estimated
                the in-hospital RSV-ALRI mortality by combining in-hospital case
                fatality ratios with hospital admission estimates from
                hospital-based (published and unpublished) studies. We also
                estimated overall RSV-ALRI mortality by identifying studies
                reporting monthly data for ALRI mortality in the community and
                RSV activity. FINDINGS: We estimated that globally in 2015, 33.1
                million (uncertainty range [UR] 21.6-50.3) episodes of RSV-ALRI,
                resulted in about 3.2 million (2.7-3.8) hospital admissions, and
                59 600 (48 000-74 500) in-hospital deaths in children younger
                than 5 years. In children younger than 6 months, 1.4 million (UR
                1.2-1.7) hospital admissions, and 27 300 (UR 20 700-36 200)
                in-hospital deaths were due to RSV-ALRI. We also estimated that
                the overall RSV-ALRI mortality could be as high as 118 200 (UR
                94 600-149 400). Incidence and mortality varied substantially
                from year to year in any given population. INTERPRETATION:
                Globally, RSV is a common cause of childhood ALRI and a major
                cause of hospital admissions in young children, resulting in a
                substantial burden on health-care services. About 45% of
                hospital admissions and in-hospital deaths due to RSV-ALRI occur
                in children younger than 6 months. An effective maternal RSV
                vaccine or monoclonal antibody could have a substantial effect
                on disease burden in this age group. FUNDING: The Bill &
                Melinda Gates Foundation.

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Global, regional, and national disease burden estimates of acute
                lower respiratory infections due to respiratory syncytial virus
                in young children in 2015: a systematic review and modelling
                study