# name
Metallic pseudopeptidic macrocycles. Study of molecular recognition processes of amino acids

# metadata.dc.description[].value
Treballs Finals de Grau de Química, Facultat de Química, Universitat de Barcelona, Any: 2014, Tutors: Dra. Laura Rodríguez Raurell i Dr. Ignacio Alfonso Rodríguez

# metadata.dc.description.abstract[].value
The aim of this work is the synthesis of the chiral pseudopeptidic macrocycle 5b and its use, together with analogue macrocycle 5a (Scheme 1) as ligands for Cu2+, in molecular recognition processes of amino acids. The two dinuclear complexes will be used as receptors in molecular recognition processes. The synthesis of the [2+2] pseudopeptidic macrocycle through a reductive amination is carried out by using an anionic template which places the four subunits in the right orientation for their union. The obtained product is characterized by ESI-MS and NMR. Copper complexes are prepared starting with the meta macrocycle and its para analogue. The resulting products are characterized by ESI MS.
A comparative study of many amino acids and analogues behavior with the two macrocyclic complexes is carried out by UV-Vis spectrophotometry. After that, recognition tests are made with the two possible Malate isomers and association constants values are calculated for both isomers with macrocyclic copper complex.

# metadata.dc.title[].value
Metallic pseudopeptidic macrocycles. Study of molecular recognition processes of amino acids

# metadata.dc.title.alternative[].value
Macrocicles pseudopeptídics metàl·lics. Estudi de processos de reconeixement molecular d'aminoàcids