# name
IgG antibodies to synthetic GPI are biomarkers of immune-status
                to both Plasmodium falciparum and Plasmodium vivax malaria in
                young children

# metadata.dc.description.abstract[].value
BACKGROUND: Further reduction in malaria prevalence and its
                eventual elimination would be greatly facilitated by the
                development of biomarkers of exposure and/or acquired immunity
                to malaria, as well as the deployment of effective vaccines
                against Plasmodium falciparum and Plasmodium vivax. A better
                understanding of the acquisition of immunity in
                naturally-exposed populations is essential for the
                identification of antigens useful as biomarkers, as well as to
                inform rational vaccine development. METHODS: ELISA was used to
                measure total IgG to a synthetic form of
                glycosylphosphatidylinositol from P. falciparum (PfGPI) in a
                cohort of 1-3 years old Papua New Guinea children with
                well-characterized individual differences in exposure to P.
                falciparum and P. vivax blood-stage infections. The relationship
                between IgG levels to PfGPI and measures of recent and past
                exposure to P. falciparum and P. vivax infections was
                investigated, as well as the association between antibody levels
                and prospective risk of clinical malaria over 16 months of
                follow-up. RESULTS: Total IgG levels to PfGPI were low in the
                young children tested. Antibody levels were higher in the
                presence of P. falciparum or P. vivax infections, but
                short-lived. High IgG levels were associated with higher risk of
                P. falciparum malaria (IRR 1.33-1.66, P = 0.008-0.027),
                suggesting that they are biomarkers of increased exposure to P.
                falciparum infections. Given the cross-reactive nature of
                antibodies to PfGPI, high IgG levels were also associated with
                reduced risk of P. vivax malaria (IRR 0.65-0.67, P =
                0.039-0.044), indicating that these antibodies are also markers
                of acquired immunity to P. vivax. CONCLUSIONS: This study
                highlights that in young children, IgG to PfGPI might be a
                useful marker of immune-status to both P. falciparum and P.
                vivax infections, and potentially useful to help malaria control
                programs to identify populations at-risk. Further functional
                studies are necessary to confirm the potential of PfGPI as a
                target for vaccine development.

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
IgG antibodies to synthetic GPI are biomarkers of immune-status
                to both Plasmodium falciparum and Plasmodium vivax malaria in
                young children