# name
Antimalarial Activity of Orally Administered Curcumin Incorporated in Eudragit((R))-Containing Liposomes

# metadata.dc.description.abstract[].value
Curcumin is an antimalarial compound easy to obtain and
                inexpensive, having shown little toxicity across a diverse
                population. However, the clinical use of this interesting
                polyphenol has been hampered by its poor oral absorption,
                extremely low aqueous solubility and rapid metabolism. In this
                study, we have used the anionic copolymer Eudragit(®)
                S100 to assemble liposomes incorporating curcumin and containing
                either hyaluronan (Eudragit-hyaluronan liposomes) or the
                water-soluble dextrin Nutriose(®) FM06
                (Eudragit-nutriosomes). Upon oral administration of the
                rehydrated freeze-dried nanosystems administered at 25/75 mg
                curcumin·kg(−1)·day(−1), only Eudragit-nutriosomes improved the in vivo antimalarial activity of curcumin in a dose-dependent manner, by enhancing the survival of all Plasmodium yoelii-infected mice up to 11/11 days, as compared to 6/7 days upon administration of an equal dose of the free compound. On the other hand, animals treated with curcumin incorporated in Eudragit-hyaluronan liposomes did not live longer than the controls, a result consistent with the lower stability of this formulation after reconstitution. Polymer-lipid nanovesicles hold promise for their development into systems for the oral delivery of curcumin-based antimalarial therapies.

# metadata.dc.relation.isformatof[].value
Reproducció del document publicat a:
                http://dx.doi.org/10.3390/ijms19051361

# metadata.dc.relation.ispartof[].value
International Journal of Molecular Sciences, 2018, vol. 19, num.
                5, p. E1361

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Antimalarial Activity of Orally Administered Curcumin Incorporated in Eudragit((R))-Containing Liposomes