# name
Tumor necrosis factor-alpha mediates changes in tissue protein turnover in a rat cancer cachexia model.

# metadata.dc.description.abstract[].value
Rats bearing the Yoshida AH-130 ascites hepatoma showed enhanced fractional rates of protein degradation in gastrocnemius muscle, heart, and liver, while fractional synthesis rates were similar to those in non-tumor bearing rats. This hypercatabolic pattern was associated with marked perturbations of the hormonal homeostasis and presence of tumor necrosis factor in the circulation. The daily administration of a goat anti-murine TNF IgG to tumor-bearing rats decreased protein degradation rates in skeletal muscle, heart, and liver as compared with tumor-bearing rats receiving a nonimmune goat IgG. The anti-TNF treatment was also effective in attenuating early perturbations in insulin and corticosterone homeostasis. Although these results suggest that tumor necrosis factor plays a significant role in mediating the changes in protein turnover and hormone levels elicited by tumor growth, the inability of such treatment to prevent a reduction in body weight implies that other mediators or tumor-related events were also involved.

# metadata.dc.publisher[].value
American Society for Clinical Investigation

# metadata.dc.relation.ispartof[].value
Journal of Clinical Investigation, 1993, vol. 92, núm. 6, p. 2783-2789.

# metadata.dc.rights[].value
(c) The American Society for Clinical Investigation, 1993

# metadata.dc.source[].value
Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

# metadata.dc.title[].value
Tumor necrosis factor-alpha mediates changes in tissue protein turnover in a rat cancer cachexia model.