# name
High proportions of asymptomatic and submicroscopic Plasmodium
                vivax infections in a peri-urban area of low transmission in the
                Brazilian Amazon

# metadata.dc.description.abstract[].value
BACKGROUND: Population-based studies conducted in Latin America
                have shown a high proportion of asymptomatic and submicroscopic
                malarial infections. Considering efforts aiming at regional
                elimination, it is important to investigate the role of this
                asymptomatic reservoir in malaria transmission in peri-urban
                areas. This study aimed to estimate the prevalence of Plasmodium
                spp. and gametocyte burden on symptomatic and asymptomatic
                infections in the Brazilian Amazon. RESULTS: Two cross-sectional
                household surveys (CS) were conducted including all inhabitants
                in a peri-urban area of Manaus, western Amazonas State, Brazil.
                Malaria parasites were detected by light microscopy (LM) and
                qPCR. Sexual stages of Plasmodium spp. were detected by LM and
                RT-qPCR. A total of 4083 participants were enrolled during the
                two surveys. In CS1, the prevalence of Plasmodium vivax
                infections was 4.3% (86/2010) by qPCR and 1.6% (32/2010) by LM.
                Fifty percent (43/86) of P. vivax infected individuals (qPCR)
                carried P. vivax gametocytes. In CS2, 3.4% (70/2073) of
                participants had qPCR-detectable P. vivax infections, of which
                42.9% (30/70) of infections were gametocyte positive. The P.
                vivax parasite density was associated with gametocyte carriage
                (P < 0.001). Sixty-seven percent of P. vivax infected
                individuals and 53.4% of P. vivax gametocyte carriers were
                asymptomatic. CONCLUSIONS: This study confirms a substantial
                proportion of asymptomatic and submicroscopic P. vivax
                infections in the study area. Most asymptomatic individuals
                carried gametocytes and presented low asexual parasitemia. This
                reservoir actively contributes to malaria transmission in the
                Brazilian Amazon, underscoring a need to implement more
                efficient control and elimination strategies.

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
High proportions of asymptomatic and submicroscopic Plasmodium
                vivax infections in a peri-urban area of low transmission in the
                Brazilian Amazon