# name
Concentration and avidity of antibodies to different
                circumsporozoite epitopes correlate with RTS,S/AS01E malaria
                vaccine efficacy

# metadata.dc.description.abstract[].value
RTS,S/AS01E has been tested in a phase 3 malaria vaccine
                study with partial efficacy in African children and infants. In
                a cohort of 1028 subjects from one low (Bagomoyo) and two high
                (Nanoro, Kintampo) malaria transmission sites, we analysed IgG
                plasma/serum concentration and avidity to CSP (NANP-repeat and
                C-terminal domains) after a 3-dose vaccination against time to
                clinical malaria events during 12-months. Here we report that
                RTS,S/AS01E induces substantial increases in IgG levels from
                pre- to post-vaccination (p\xE2\x80\x89<\xE2\x80\x890.001),
                higher in NANP than C-terminus (2855 vs 1297 proportional change
                between means), and higher concentrations and avidities in
                children than infants (p\xE2\x80\x89<\xE2\x80\x890.001).
                Baseline CSP IgG levels are elevated in malaria cases than
                controls (p\xE2\x80\x89<\xE2\x80\x890.001). Both, IgG
                magnitude to NANP (hazard ratio [95% confidence interval] 0.61
                [0.48-0.76]) and avidity to C-terminus (0.07 [0.05-0.90])
                post-vaccination are significantly associated with vaccine
                efficacy. IgG avidity to the C-terminus emerges as a significant
                contributor to RTS,S/AS01E-mediated protection.

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Concentration and avidity of antibodies to different
                circumsporozoite epitopes correlate with RTS,S/AS01E malaria
                vaccine efficacy