# name
Salmonella enterica serovars Typhimurium and Enteritidis causing
                mixed infections in febrile children in Mozambique

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Background and purpose: Invasive nontyphoidal salmonellosis,
                mostly caused by serovars Typhimurium and Enteritidis of
                Salmonella enterica, has emerged as a major public health
                problem in sub-Saharan Africa. The aim of this study was the
                clinical and microbiological characterization of nontyphoidal
                salmonellosis episodes affecting febrile children in Mozambique.
                Patients and methods: The clinical records of the patients were
                evaluated, and S. enterica isolates were characterized with
                regard to serovar, phage type, antimicrobial resistance
                (phenotype/responsible genes), plasmid content, pulsed-field gel
                electrophoresis, and multilocus sequence typing. Results:
                Fifteen S. Typhimurium and 21 S. Enteritidis isolates were
                recovered from blood samples of 25 children, the majority with
                underlying risk factors. With regard to phage typing, most
                isolates were either untypeable or reacted but did not conform,
                revealing that a number of previously unrecognized patterns are
                circulating in Mozambique. Most isolates were
                multidrug-resistant, with nearly all of the responsible genes
                located on derivatives of serovar-specific virulence plasmids.
                ST313 and ST11 were the predominant sequence types associated
                with S. Typhimurium and S. Enteritidis, respectively, and the
                uncommon ST1479 was also detected in S. Enteritidis. A distinct
                XbaI fragment of ~350 kb was associated with pulsed-field gel
                electrophoresis patterns of multidrug-resistant isolates of S.
                Enteritidis. Nearly half of the children were coinfected with
                both serovars, a fact expected to aggravate the disease and
                hamper the treatment. However, particularly poor outcomes were
                not observed for the coinfected patients. Conclusion: Mixed
                Salmonella infections could frequently occur in febrile children
                in Mozambique. Additional studies are required to determine
                their actual impact and consequences, not only in this country,
                but also in other African countries.

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Reproducció del document publicat a:
                http://dx.doi.org/10.2147/IDR.S147243

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Infection and Drug Resistance, 2018, vol. 11, p. 195-204

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Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Salmonella enterica serovars Typhimurium and Enteritidis causing
                mixed infections in febrile children in Mozambique