# name
The Role of Mitochondria in Mood Disorders: From Physiology to Pathophysiology and to Treatment

# metadata.dc.description.abstract[].value
Mitochondria are cellular organelles involved in several biological processes, especially
in energy production. Several studies have found a relationship between mitochondrial
dysfunction and mood disorders, such as major depressive disorder and bipolar disorder.
Impairments in energy production are found in these disorders together with higher
levels of oxidative stress. Recently, many agents capable of enhancing antioxidant
defenses or mitochondrial functioning have been studied for the treatment of mood
disorders as adjuvant therapy to current pharmacological treatments. A better knowledge
of mitochondrial physiology and pathophysiology might allow the identification of new
therapeutic targets and the development and study of novel effective therapies to
treat these specific mitochondrial impairments. This could be especially beneficial for
treatment-resistant patients. In this article, we provide a focused narrative review of the
currently available evidence supporting the involvement of mitochondrial dysfunction
in mood disorders, the effects of current therapies on mitochondrial functions, and
novel targeted therapies acting on mitochondrial pathways that might be useful for the
treatment of mood disorders.

# metadata.dc.rights[].value
cc-by (c)  Giménez-Palomo, A. et al., 2021

# metadata.dc.source[].value
Articles publicats en revistes (Medicina)

# metadata.dc.title[].value
The Role of Mitochondria in Mood Disorders: From Physiology to Pathophysiology and to Treatment