# name
Plasma-derived extracellular vesicles from Plasmodium vivax
                patients signal spleen fibroblasts via NF-kB facilitating
                parasite cytoadherence.

# metadata.dc.description.abstract[].value
Plasmodium vivax is the most widely distributed human
                malaria parasite. Previous studies have shown that circulating
                microparticles during P. vivax acute attacks are indirectly
                associated with severity. Extracellular vesicles (EVs) are
                therefore major components of circulating plasma holding
                insights into pathological processes. Here, we demonstrate that
                plasma-derived EVs from Plasmodium vivax patients (PvEVs) are
                preferentially uptaken by human spleen fibroblasts (hSFs) as
                compared to the uptake of EVs from healthy individuals.
                Moreover, this uptake induces specific upregulation of ICAM-1
                associated with the translocation of NF-kB to the nucleus. After
                this uptake, P. vivax-infected reticulocytes obtained from
                patients show specific adhesion properties to hSFs, reversed by
                inhibiting NF-kB translocation to the nucleus. Together, these
                data provide physiological EV-based insights into the mechanisms
                of human malaria pathology and support the existence of P.
                vivax-adherent parasite subpopulations in the microvasculature
                of the human spleen.

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Plasma-derived extracellular vesicles from Plasmodium vivax
                patients signal spleen fibroblasts via NF-kB facilitating
                parasite cytoadherence.