# name
IP-10 Levels as an Accurate Screening Tool to Detect Acute HIV
                Infection in Resource-Limited Settings

# metadata.dc.description.abstract[].value
Acute HIV infection (AHI) is the period prior to seroconversion
                characterized by high viral replication, hyper-transmission
                potential and commonly, non-specific febrile illness. AHI
                detection requires HIV-RNA viral load (VL) determination, which
                has very limited access in low-income countries due to
                restrictive costs and implementation constraints. We sought to
                identify a biomarker that could enable AHI diagnosis in
                scarce-resource settings, and to evaluate the feasibility of its
                implementation. HIV-seronegative adults presenting at the
                Manhica District Hospital, Mozambique, with reported-fever were
                tested for VL. Plasma levels of 49 inflammatory biomarkers from
                AHI (n = 61) and non-HIV infected outpatients (n = 65) were
                determined by Luminex and ELISA. IP-10 demonstrated the best
                predictive power for AHI detection (AUC = 0.88 [95%CI
                0.80-0.96]). A cut-off value of IP-10 >/= 161.6 pg/mL
                provided a sensitivity of 95.5% (95%CI 85.5-99.5) and a
                specificity of 76.5% (95%CI 62.5-87.2). The implementation of an
                IP-10 screening test could avert from 21 to 84 new infections
                and save from US$176,609 to US$533,467 to the health system per
                1,000 tested patients. We conclude that IP-10 is an accurate
                biomarker to screen febrile HIV-seronegative individuals for
                subsequent AHI diagnosis with VL. Such an algorithm is a
                cost-effective strategy to prevent disease progression and a
                substantial number of further HIV infections.

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
IP-10 Levels as an Accurate Screening Tool to Detect Acute HIV
                Infection in Resource-Limited Settings