# name
Discovery of non-nucleoside inhibitors of HIV-1 reverse transcriptase competing with the nucleotide substrate

# metadata.dc.description.abstract[].value
How odd! A new class of non-nucleoside reverse transcriptase inhibitors with a 6-vinylpyrimidine scaffold (1) has been found to inhibit HIV-1 reverse transcriptase (RT) by competition with the nucleotide substrate after binding to the non-nucleoside inhibitor binding pocket of the enzyme. Molecular modeling studies have been performed to elucidate their peculiar behavior.

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Angewandte Chemie-International Edition, 2007, vol. 46, num. 11, p. 1810-1813

# metadata.dc.source[].value
Articles publicats en revistes (Química Inorgànica i Orgànica)

# metadata.dc.title[].value
Discovery of non-nucleoside inhibitors of HIV-1 reverse transcriptase competing with the nucleotide substrate