# name
Multimorbidity as specific disease combinations, an important
                predictor factor for mortality in octogenarians: the Octabaix
                study

# metadata.dc.description.abstract[].value
BACKGROUND: The population is aging and multimorbidity is
                becoming a common problem in the elderly. OBJECTIVE: To explore
                the effect of multimorbidity patterns on mortality for all
                causes at 3- and 5-year follow-up periods. MATERIALS AND
                METHODS: A prospective community-based cohort (2009-2014)
                embedded within a randomized clinical trial was conducted in
                seven primary health care centers, including 328 subjects aged
                85 years at baseline. Sociodemographic variables, sensory
                status, cardiovascular risk factors, comorbidity, and geriatric
                tests were analyzed. Multimorbidity patterns were defined as
                combinations of two or three of 16 specific chronic conditions
                in the same individual. RESULTS: Of the total sample, the median
                and interquartile range value of conditions was 4 (3-5). The
                individual morbidities significantly associated with death were
                chronic obstructive pulmonary disease (COPD; hazard ratio [HR]:
                2.47; 95% confidence interval [CI]: 1.3; 4.7), atrial
                fibrillation (AF; HR: 2.41; 95% CI: 1.3; 4.3), and malignancy
                (HR: 1.9; 95% CI: 1.0; 3.6) at 3-year follow-up; whereas
                dementia (HR: 2.04; 95% CI: 1.3; 3.2), malignancy (HR: 1.84; 95%
                CI: 1.2; 2.8), and COPD (HR: 1.77; 95% CI: 1.1; 2.8) were the
                most associated with mortality at 5-year follow-up, after
                adjusting using Barthel functional index (BI). The two
                multimorbidity patterns most associated with death were AF,
                chronic kidney disease (CKD), and visual impairment (HR: 4.19;
                95% CI: 2.2; 8.2) at 3-year follow-up as well as hypertension,
                CKD, and malignancy (HR: 3.24; 95% CI: 1.8; 5.8) at 5 years,
                after adjusting using BI. CONCLUSION: Multimorbidity as specific
                combinations of chronic conditions showed an effect on
                mortality, which would be higher than the risk attributable to
                individual morbidities. The most important predicting pattern
                for mortality was the combination of AF, CKD, and visual
                impairment after 3 years. These findings suggest that a new
                approach is required to target multimorbidity in octogenarians.

# metadata.dc.relation.isformatof[].value
Reproducció del document publicat a:
                http://dx.doi.org/10.2147/CIA.S123173

# metadata.dc.relation.ispartof[].value
Clinical Interventions in Aging, 2017, vol. 12, p.
                223-231

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Multimorbidity as specific disease combinations, an important
                predictor factor for mortality in octogenarians: the Octabaix
                study