# name
Metaanalysis of the Performance of a Combined Treponemal and
                Nontreponemal Rapid Diagnostic Test for Syphilis and Yaws

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BACKGROUND: The human treponematoses are important causes of
                disease. Mother-to-child transmission of syphilis remains a
                major cause of stillbirth and neonatal death. There are also
                almost 100 000 cases of endemic treponemal disease reported
                annually, predominantly yaws. Rapid diagnostic tests (RDTs)
                would improve access to screening for these diseases. Most RDTs
                cannot distinguish current and previous infection. The Dual Path
                Platform (DPP) Syphilis Screen & Confirm test includes both
                a treponemal (T1) and nontreponemal (T2) component and may
                improve the accuracy of diagnosis. METHODS: We conducted a
                metaanalysis of published and unpublished evaluations of the
                DPP-RDT for the diagnosis of syphilis and yaws. We calculated
                the sensitivity, specificity, and overall agreement of the test
                compared with reference laboratory tests. RESULTS: Nine
                evaluations, including 7267 tests, were included. Sensitivity
                was higher in patients with higher titer rapid plasma reagin
                (>/=1:16) for both the T1 (98.2% vs 90.1%, P < .0001) and
                the T2 component (98.2% vs 80.6%, P < .0001). Overall
                agreement between the DPP test and reference serology was 85.2%
                (84.4%-86.1%). Agreement was highest for high-titer active
                infection and lowest for past infection. CONCLUSIONS: The RDT
                has good sensitivity and specificity of the treponemal and
                nontreponemal components both in cases of suspected syphilis and
                yaws, although the sensitivity is decreased at lower antibody
                titers.

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Reproducció del document publicat a:
                http://dx.doi.org/10.1093/cid/ciw348

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Clinical Infectious Diseases, 2016, vol. 65, num. 5, p. 627-633

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Metaanalysis of the Performance of a Combined Treponemal and
                Nontreponemal Rapid Diagnostic Test for Syphilis and Yaws