# name
HPV-negative tumors of the uterine cervix

# metadata.dc.description.abstract[].value
Human papillomaviruses (HPV) are the causative agents of
                virtually all cervical carcinomas. Nevertheless, a small
                proportion of cervical cancer are negative for HPV, although the
                significance of this finding remains unclear. We aimed to
                provide insight into the differential clinico-pathological
                characteristics of this unusual subset of HPV-negative cervical
                cancer. We performed HPV-DNA detection using a highly sensitive
                PCR test (SPF10) and p16 immunostaining in 214 cervical
                carcinomas specimens from women treated at the Gynecological
                Oncology Unit of the Hospital Clinic (Barcelona, Spain) from
                2012 to 2015. The clinical and pathological characteristics,
                including disease-free survival and overall survival, of
                HPV-negative and -positive cervical carcinomas were compared.
                Twenty-one out of 214 tumors (10%) were negative for HPV DNA.
                HPV-negative tumors were more frequently of the non-squamous
                type (9/21, 43% vs. 37/193, 19%;
                p\xE2\x80\x89<\xE2\x80\x890.01) and showed negative p16
                staining (9/21; 43% vs. 7/193; 4%;
                p\xE2\x80\x89<\xE2\x80\x890.01). HPV-negative tumors were
                more frequently diagnosed at advanced FIGO stage (19/21, 91% vs.
                110/193, 57%; p\xE2\x80\x89<\xE2\x80\x890.01) and more
                frequently had lymph node metastases (14/21, 67% vs. 69/193,
                36%; p\xE2\x80\x89<\xE2\x80\x890.01). Patients with
                HPV-negative cervical cancer had a significantly worse
                disease-free survival (59.8 months, 95% confidence interval
                32.0-87.6 vs. 132.2 months, 95% confidence interval 118.6-145.8;
                p\xE2\x80\x89<\xE2\x80\x890.01) and overall survival (77.0
                months, 95% confidence interval 47.2-106.8 vs. 153.8 months, 95%
                confidence interval 142.0-165.6; p\xE2\x80\x89=\xE2\x80\x890.01)
                than women with HPV-positive tumors. However, only advanced FIGO
                stage and lymph node metastases remained associated with a poor
                disease-free survival and overall survival on multivariate
                analysis. In conclusion, our results suggest that a low
                percentage of cervical cancer arise via an HPV-independent
                pathway. These HPV-negative tumors are diagnosed at advanced
                stages, show higher prevalence of lymph nodes metastases and
                have an impaired prognosis.

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
HPV-negative tumors of the uterine cervix