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Fatal Langerhans Cell Histiocytosis in an 84-Year-Old Man: A Case Report

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Langerhans cell histiocytosis (LCH) is a rare myeloid neoplastic disorder with highly variable clinical presentations. In this article, we describe an unusual case of an 84-year-old man with initial focal truncal LCH who later developed multisystem involvement, including severe hepatic infiltration leading to fulminant hepatic failure. This case highlights the diagnostic challenge of differentiating LCH hepatic involvement from methotrexate toxicity and the poor prognosis associated with hepatic LCH. Early recognition and a multidisciplinary approach are crucial for improving outcomes in patients with multisystem LCH.

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American Journal of Dermatopathology, 2025, vol. 47, num. 8, p. 648-650

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Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

# metadata.dc.title[].value
Fatal Langerhans Cell Histiocytosis in an 84-Year-Old Man: A Case Report