# name
Synthesis and antitumor activity of mechercharmycin A analogues

# metadata.dc.description.abstract[].value
Several analogs of the cytotoxic thiopeptide IB-01211 or Mechercharmycin A (1) have been synthetized. The cytotoxicity of 1 and the synthetized analogs was evaluated against a panel of three human tumor cell lines. Thiopeptide 1 and the most active derivatives, 2 and 3c, were chosen for further studies like effects on cell cycle progression and induction of apoptosis. Interestingly, the inhibition of cell division and activation of a programmed cell death by apoptosis was detected.

# metadata.dc.source[].value
Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

# metadata.dc.subject.classification[].value
Espectroscòpia de ressonància magnètica nuclear

# metadata.dc.title[].value
Synthesis and antitumor activity of mechercharmycin A analogues