# name
Improved Alere Determine Lipoarabinomannan Antigen Detection
                Test for the Diagnosis of Human and Bovine Tuberculosis by
                Manipulating Urine and Milk

# metadata.dc.description.abstract[].value
Tuberculosis (TB) disease still kills 1-person every
                21-seconds. Few TB diagnostic tests are considered truly
                appropriate for point of care settings. The WHO-endorsed
                immunodiagnostic Alere Determine Lipoarabinomannan Ag-test
                (LAM-test) detects Mycobacterium tuberculosis complex LAM in
                urine, and its use is recommended for TB diagnosis among HIV
                co-infected individuals with low CD4 T-cell counts. Here we
                found that a simple 15-minute enzymatic treatment at room
                temperature of LAM-spiked urine with \xCE\xB1-mannosidase (for
                human TB), and LAM-spiked milk with combined lactase and
                caseinase (for bovine TB), enhanced 10-fold the detection levels
                of the LAM-test and thus, improved the detection of LAM by the
                LAM-test in urine and milk that otherwise could be missed in the
                field. Future separate clinical research studies specifically
                designed to address the potential of these findings are
                required.

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Improved Alere Determine Lipoarabinomannan Antigen Detection
                Test for the Diagnosis of Human and Bovine Tuberculosis by
                Manipulating Urine and Milk