# name
The effect of the neutral cytidine protonated analogue pseudoisocytidine on the stability of i-motif structures

# metadata.dc.description.abstract[].value
Incorporation of pseudoisocytidine (psC), a neutral analogue of protonated cytidine, in i-motifs has been studied by spectroscopic methods. Our results show that neutral psC:C base pairs can stabilize i-motifs at neutral pH, but the stabilization only occurs when psC:C base pairs are located at the ends of intercalated C:C+ stacks. When psC occupies central positions, the resulting i-motifs are only observed at low pH and psC:C+ or psC:psC+ hemiprotonated base pairs are formed instead of their neutral analogs. Overall, our results suggest that positively charged base pairs are necessary to stabilize this non-canonical DNA structure.

# metadata.dc.relation.ispartof[].value
Scientific Reports, 2017, vol. 7, num. 2772

# metadata.dc.rights[].value
cc-by (c) Mir Morro, Bartomeu et al., 2017

# metadata.dc.source[].value
Articles publicats en revistes (Química Inorgànica i Orgànica)

# metadata.dc.title[].value
The effect of the neutral cytidine protonated analogue pseudoisocytidine on the stability of i-motif structures