# name
Special issue: G protein-coupled adenosine receptors: molecular aspects and beyond

# metadata.dc.description.abstract[].value
Adenosine is a purine nucleoside present in all human cells where it plays many different physiological roles: From being a building block for nucleic acids to a key constituent of the biological energy currency ATP. Indeed, more than 90 years ago, Drury and Szent-Györgyi reported that adenosine produces profound hypotension and bradycardia, and until the present time, the list of physiological effects of adenosine has expanded considerably. In addition, adenosine is a well-known neuromodulator in the brain and has effects on other tissues, thus exerting its physiological actions through four different subtypes of G protein-coupled adenosine receptors (i.e., A1R, A2AR, A2BR and A3R) which, as expected, are expressed in a large variety of cells throughout the body. Consequently, ARs are potential therapeutic targets in a variety of pathophysiological conditions, including cancer, cardiovascular diseases, neurological disorders, and inflammatory and autoimmune diseases.

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International Journal of Molecular Sciences, 2020, vol. 21, num. 6, p. 1997

# metadata.dc.rights[].value
cc-by (c) Ciruela Alférez, Francisco, 2020

# metadata.dc.source[].value
Articles publicats en revistes (Patologia i Terapèutica Experimental)

# metadata.dc.title[].value
Special issue: G protein-coupled adenosine receptors: molecular aspects and beyond