# name
Samarium(II) folding cascades involving hydrogen atom transfer for the synthesis of complex polycycles

# metadata.dc.description.abstract[].value
The expedient assembly of complex, natural product-like small molecules can deliver new chemical entities with the potential to interact with biological systems and inspire the development of new drugs and probes for biology. Diversity-oriented synthesis is a particularly attractive strategy for the delivery of complex molecules in which the 3-dimensional architecture varies across the collection. Here we describe a folding cascade approach to complex polycyclic systems bearing multiple stereocentres mediated by reductive single electron transfer (SET) from SmI2. Simple, linear substrates undergo three different folding pathways triggered by reductive SET. Two of the radical cascade pathways involve the activation and functionalization of otherwise inert secondary alkyl and benzylic groups by 1,5-hydrogen atom transfer (HAT). Combination of SmI2, a privileged reagent for cascade reactions, and 1,5-HAT can lead to complexity-generating radical sequences that unlock access to diverse structures not readily accessible by other means.

# metadata.dc.relation.ispartof[].value
Nature Communications, 2018, vol. 9, p. 4802

# metadata.dc.rights[].value
cc-by (c) Plesniak, Mateusz P. et al., 2018

# metadata.dc.source[].value
Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

# metadata.dc.title[].value
Samarium(II) folding cascades involving hydrogen atom transfer for the synthesis of complex polycycles