# name
A metagenomic study of patients with alveolar osteitis after tooth extraction. A preliminary case-control study

# metadata.dc.description.abstract[].value
Objective: To identify the microbiome in sockets with alveolar osteitis and compare it with a control group using metagenomic techniques. Materials and methods: A case-control study was conducted in subjects that had undergone a tooth extraction. Microbiological samples were taken from the sockets of 10 patients with dry socket after tooth extraction (AO group) and 10 patients in whom exodontia resulted in no postoperative complications (control group). Bacterial DNA was isolated, and the 16S rRNA gene was amplified and sequenced. Multiplexed tag-encoded sequencing of DNA from the samples was performed, and the reads were processed by Metagenomic Rapid Annotation. Results: A total of 151 different species were found: 55 bacteria were only found in the AO group, 51 were specific to the control group, and 45 were common to both groups. The most frequently found genera in both groups were Prevotella. Prevotella nanceiensis, Actinomyces odontolyticus, Treponema maltophilum, Veillonella dispar, Tannerella forsythia, and Leuconostoc mesenteroides were found in several patients with alveolar osteitis, with an abundance greater than 0.5%, and were absent in all the control group samples. Conclusions: Patients who develop alveolar osteitis after dental extractions might have a different microbiota from that of patients without postoperative complications. Since this is a preliminary report, further research is needed to assess whether bacteria play an important role in the etiology of dry socket. Clinical relevance: This study seems to indicate that bacteria may play an important role in the alveolar osteitis etiology. Thus, new prevention and treatment strategies should be considered.

# metadata.dc.rights[].value
(c) German Society of Oral and Maxillofacial Surgery, 2019

# metadata.dc.title[].value
A metagenomic study of patients with alveolar osteitis after tooth extraction. A preliminary case-control study