# name
Interferon-gamma-Inducible Protein 10 (IP-10) as a Screening
                Tool to Optimize Human Immunodeficiency Virus RNA Monitoring in
                Resource-Limited Settings

# metadata.dc.description.abstract[].value
Background: Achieving effective antiretroviral treatment (ART)
                monitoring is a key determinant to ensure viral suppression and
                reach the UNAIDS 90-90-90 targets. The gold standard for
                detecting virological failure is plasma human immunodeficiency
                virus (HIV) RNA (viral load [VL]) testing; however, its
                availability is very limited in low-income countries due to cost
                and operational constraints. Methods: HIV-1-infected adults on
                first-line ART attending routine visits at the Manhica District
                Hospital, Mozambique, were previously evaluated for virologic
                failure. Plasma levels of interferon-gamma-inducible protein 10
                (IP-10) were quantified by enzyme-linked immunosorbent assay.
                Logistic regression was used to build an IP-10-based model able
                to identify individuals with VL >150 copies/mL. From the 316
                individuals analyzed, 253 (80%) were used for model training and
                63 (20%) for validation. Receiver operating characteristic
                curves were employed to evaluate model prediction. Results: From
                the individuals included in the training set, 34% had detectable
                VL. Mean age was 41 years, 70% were females, and median time on
                ART was 3.4 years. IP-10 levels were significantly higher in
                subjects with detectable VL (108.2 pg/mL) as compared to those
                with undetectable VL (38.0 pg/mL) (P < .0001, U test). IP-10
                univariate model demonstrated high classification performance
                (area under the curve = 0.85 [95% confidence interval {CI},
                .80-.90]). Using a cutoff value of IP-10 >/=44.2 pg/mL, the
                model identified detectable VL with 91.9% sensitivity (95% CI,
                83.9%-96.7%) and 59.9% specificity (95% CI, 52.0%-67.4%), values
                confirmed in the validation set. Conclusions: IP-10 is an
                accurate biomarker to screen individuals on ART for detectable
                viremia. Further studies should evaluate the benefits of IP-10
                as a triage approach to monitor ART in resource-limited
                settings.

# metadata.dc.relation.isformatof[].value
Reproducció del document publicat a:
                http://dx.doi.org/10.1093/cid/cix600

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Interferon-gamma-Inducible Protein 10 (IP-10) as a Screening
                Tool to Optimize Human Immunodeficiency Virus RNA Monitoring in
                Resource-Limited Settings