# name
11B-HSD1 inhibition rescues cognitive disturbances after chronic mild stress in mice: target engagement determination through TAPS assay

# metadata.dc.description.abstract[].value
With the increase in life expectancy, the study of age-related diseases and the development of different strategies to deal with them become mandatory. Cognitive
and behavioural disturbances are growing public healthcare issue for the modern society, which is experiencing an increasingly common stressful lifestyle. Taking
into consideration the convergence of aging, stress and neurodegenerative diseases, such as AD, there is impaired glucocorticoid (GC) signalling. Therefore, the
study of GC-mediated stress response to chronic moderate stressful (CMS) situations, as account in the daily life, becomes of huge interest in order to design
pharmacological strategies to prevent neurodegeneration. Several pieces of evidence link the inhibition of 11β-HSD1 with reduction of GC levels and cognitive
improvement, while CMS exposure has been associated with reduced cognitive performance.
The aim of this project was to assess whether RL-118 treatment, an 11β-HSD1 inhibitor, could restore the deleterious effects of CMS on cognition and behavioural
abilities, but also acts on molecular mechanisms that compromise healthy aging in SAMP8 mice.

# metadata.dc.relation.ispartof[].value
Comunicació a Webinar on Pharmacology on June 19, 2020

# metadata.dc.rights[].value
cc by-nc-nd (c) Puigoriol Illamola, Dolors  et al.,  2020

# metadata.dc.source[].value
Comunicacions a congressos (Farmacologia, Toxicologia i Química Terapèutica)

# metadata.dc.title[].value
11B-HSD1 inhibition rescues cognitive disturbances after chronic mild stress in mice: target engagement determination through TAPS assay